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On a separate note, this paper doesn't seem to mention any "negative aspects of the vaccine" - It seems to be concluding that [the likes of AstraZeneca etc. perform better on some measures than the mRNA favorites.] edit: I previously stated the conclusion backwards.


Not necessarily, IgG4 is a unique case:

> In a setting of HIV vaccination, a study compared repeated immunizations with two related HIV vaccine formats. The authors described that the protection of one vaccine composition correlated with the induction of IgG1 and IgG3 Abs, whereas the other vaccine composition hardly showed any protection, which correlated with the generation of IgG4 upon repeated immunizations instead.


edited; thanks


Why is higher long-term IgG4 response favorable?




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