House arrest? What a bizarre way of looking at it. Today I went and got my car fixed at the mechanic during the same period of time I would have had to vacantly stare at my monitor and pretend to be productive at a typical cubicle job. I have more freedom of movement now than I ever did with the strict 9-5 schedule at an office.
That's the thing. Offices don't have to have a 9-5 schedule. For example - just today I started working at 10am at home. I had a 30 minute remote meeting and then followed up on a couple of things before driving in at 11. I had a 1:1 over lunch with my manager. I did some code review and talked with my co-workers. Then I left at 3:30.
I got free lunch. I got to see my manager face-to-face to have a pretty serious conversation. I got free snacks.
…but you have to live driving distance from work, ruling out almost the entire planet for living in. I will add that it also rules out almost every workplace for you, and almost every employee for your business. Face to face is sometimes better, just not worth the massive tradeoffs.
Depending on where you want to live remote work will make more sense. I'm just saying the loathing that offices get can be quickly fixed by using them less and mostly for what they're good at.
Some proteins have 3D structures that look like abstract art only because we don't have an intuitive understanding of what shape and amino acids are necessary to convert chemical A to chemical B, which is the main purpose of many enzymes in the body. If you look at structural proteins or motor proteins, on the other hand, their function is clear from their shape.
There are a lot of other things you can do with the shape. If it has a pore, you can estimate the size and type of small molecule that could travel through it. You can estimate whether a binding site is accessible to the environment around it. You can determine if it forms a multimer or exists as a single unit. You can see if protein A and protein B have drastically different shapes given similar sequences, which might have implications for its druggability or understanding its function.
They are called motor proteins because they convert chemical energy into kinetic energy. In the case of kinesin, it forms a dimer (two copies of itself bind together to form the two "legs") and also binds to light chains (accessory proteins that modulate its behavior) so that it can walk along filaments and drag cargo around your cells. They are both proteins and more complex structures because multiple proteins are interacting, as well as binding small molecules and catalyzing them into chemical products, all to produce the motion.
This was my reaction, too. Anecdotally, I used to bike in a hot and humid environment. My first century ride (100+ miles in one sitting) was on a day that hit above 100 degrees with at least 80% humidity. I was able to train like that, 3-6 hours in the sun, more or less every day of the summer in similar conditions.
