Novavax UK results on par with mRNA vaccine while trials conducted with variants alpha/beta already circulating. due to unbinding or cross over we cannot really measure long term protection. but several studies show 2373 is better but nobody knows it
well we already have this protein based vaccine Novavax 2373 with cross immune response based on prototype developed 2.5 years ago. because it not only has full representation of spike protein (unlike mRNA taking shortcut to represent S protein) but also cleavage site which is omicron BA5 immune escape from.
However big pharma politics slowed down the approval, purpose delaying US P3 trial, introducing CMC requirement 1 month before formally submitting the application. Novavax 2373 has shown superb efficacy results since Jan 2021 UK trial and follow up study showed long term protection (titers half life 9months compared to mRNA 3months). no myocarditis risk. still FDA only approved it now half year after submission blaming the company's manufacture issue while it has been distributing hundred of millions of doses worldwide
mRNA is not vaccine. it is only genetic therapy
I am quite keen to research/trading engineer role in Singapore. I applied before and got interview for ops dev role. are they within same department or research engineer role demands higher skillsets?
i think US gov should set up H1B audit committee to audit all interview records and summon HR head to testify on hiring practice in the big corp. any fraud will be treated like financial fraud which results in prison term.
if students cheated in college and their parents are sentenced to 5 years, i think HR head should be treated as same
The analogy of a museum tour was exactly what inspired the name! When you want to really learn about something, it’s hard to beat the value of a guided walkthrough, that can provide you with just enough focus, while still allowing you to explore ideas on your own.
well put. I recently had this thought that dev is no difference from production line worker. There are only small fraction of dev sitting on top of pyramid designing blueprint and managing production line.
I am in this situation where I really hope I could apply some risk framework to help me make decision.
I recently signed an offer with a company, US bank with large python community. Now I am counter offered with more pay and promotion and internal transfer to a new team. Conventional wisdom is never accept counter offer. but this one I am giving second thought as it is not for original role but transferred to new team. I will be only one in my location and I will be building MVP for business users. it will be exposed to a lot of tech stack but it won't be scale as large as new company.
However to join a new company, there is always uncertainties like team and project. I had bad experience before. It is difficult to find it out through interview only. It seems to confirm this as I find that hiring process is a bit not taken seriously. It is greenfield project but no coding tests. There is no front end expertise in the team so I was only got asked things like "you worked with angularjs right?". Hiring manager is recruiting three altogether which he thinks will be good team.
risk is about managing uncertainties. I hope decision like this can be priced so it is easier to decide.
