I can't imagine that works very well for relatively small, simple, functional or intuitive projects though. Incentives wise, is it possible to sell reverse support: extracting payment for all the times the product works so well that support isn't needed?
Latency to Europe kind of is, if you want to be in a single site with acceptable ping times to Europe, US East, and US West. But I'd rather just solve replication and be in each.
Because distributing sites across multiple regions is hard -- high latency between your front end and database sucks, and replicating a database over high latency is also hard. If you can do it, great, but if you can't, then pick the best single region.
US East or US West plus Direct Connect to your own colo space, with AWS for the burst capacity, and your own redundancy for the database servers, might be the best plan if you can't do wide area "over the Internet" database replication. (I might get an extra 10G DC (since I need 1G DC myself) and then have some colo for sale with it in US East/US West later this year.)