I think Windows 10 still ships the VB runtime, but I'll go and check. Support I've come across it mainly down to third party components, be it some weird DLL or an ActiveX control that will not behave. A plain vanilla VB6 app that you might get as an ePos system or some internal CRUD tool should work 'just fine'.

Thinking about it, I am going to dig out my old VB6 VM image and have a play. Be interesting to see how many people out there would want support for VB6 apps today.