Er... I can't help you for I have never used a computer with more than 4 GB. And I was running dual monitors in the days when 256MB was a very decent setup. You had to upgrade to 32 GB RAM?
I guess I should distinguish between when I had bluescreens, and when Win10 crashed the display manager saying "your system is low on memory". And only when running on dual monitors, never on the internal 4K display (which oddly enough has more total pixels). The "out of memory" errors led me to upgrade to 32 GB.