Methotrexate is the most commonly used drug in Scandinavia when cortisones, protopic etc doesn't work. They have lot of people having these kind of issues. Good thing with methotrexate is it tends to work and it's cheap. Obviously consult your doctor before making any decision.

Humira etc is very expensive but works for lot of people that other drugs don't.

http://www.webmd.com/drugs/2/drug-3441/methotrexate-anti-rhe... https://en.wikipedia.org/wiki/Methotrexate