Many of the useful abilities in League of Legends are 'skill shots' - manually aimed, with travel time and wind-up animation, and are thus missable or dodgeable
With superhuman reflexes, a bot can be nearly immune to skillshots in a 1-on-1 scenario. A bot can also always hit skillshots, up to its accuracy of prediction of your movement, and your reflexes in dodging.
In theory, a team of humans might demonstrate better teamwork, communication, and adaptation than a team of 5 AI. However, given how much of the game depends on mechanical 1v1 conflicts, I'd expect a simple bot to beat even the most expert human players.
With superhuman reflexes, a bot can be nearly immune to skillshots in a 1-on-1 scenario. A bot can also always hit skillshots, up to its accuracy of prediction of your movement, and your reflexes in dodging.
In theory, a team of humans might demonstrate better teamwork, communication, and adaptation than a team of 5 AI. However, given how much of the game depends on mechanical 1v1 conflicts, I'd expect a simple bot to beat even the most expert human players.