As long as it's recognizable as an ad, it can be blocked. If it's not, then can you even call it an ad, really? It will be, I suppose, a very sophisticated product-placement. Certainly not something you can do automatically across millions of websites. So ad-blocking still wins.
Yes, I agree. Technically, with text classification/image recognition we can block all forms of ads, but you risk throwing out the baby with the bath water, and from my own experience, these 'plug' ads are not so repugnant, can even add an element of surprise to the content sometimes.
My point is that with adblocking tools being adopted by more users, ad platforms will perhaps begin to use this new format.