In one of the places on this list, quite near the stated "most remote spot", the realization, "Whoa, we are considering bailing off this route because of poor/dangerous conditions, and the shortest bail is about two days' walk." was quite a revelation.

When terrain and conditions are challenging enough, a few miles' distance might as well be the distance to the moon, when it comes to isolation.

If that notion pulls at you, follow it, but take small and reversible steps.