Maybe it's because I've only used fixed-width fonts for programming and have gotten used to it - but I find fixed-width fonts significantly easier on the eyes.
But would you ever read a novel using fixed width fonts? Modern typography uses variable width fonts for good reasons.
I find type writer fonts to look horrible since I’ve gotten used to variable width fonts. It’s like immediate eye strain for me. But you have to choose a good font, times new Roman won’t work.