I use Python. Anytime you need to compile the source to build a pip package and that the upstream package developer decided that they don't support Alpine's libc implementation (aka musl) then you will have a big problem, unless you can control your dependencies and include as few pip packages that requires compilation or find binary builds.
this: https://github.com/grpc/grpc/issues/18150#issuecomment-47999...
And this: https://github.com/pypa/manylinux/issues/37
I use Python. Anytime you need to compile the source to build a pip package and that the upstream package developer decided that they don't support Alpine's libc implementation (aka musl) then you will have a big problem, unless you can control your dependencies and include as few pip packages that requires compilation or find binary builds.