If you're learning letters then orientation matters unless you have extremely strict orthography. E M W 3 can all be written the same but have different orientations, for example.
My comment was about orthography, how letters are manually written; the context was learners who don't already know an alphabet.
It's not uncommon to write capital-E with cursive strokes so it's a reflected or rotated 3, and lower case m and w are sometimes written similarly - so as to be very close to rotated versions of the same character.
Yes, and OP's comment was in relation to higher level computer representation of combined forms, so as interesting as your comment is, at this point it's simply picking threads for the sake of self-amusement.