They may or may not have perfect knowledge, but if they don't have free will or any ability to randomly choose participants, then there is no reason to trust that the patients they choose are not correlated to the medicine they are testing, such that all of the patients they chose will have the maximum response possible to the medicine, with the least amount of side effects.
The whole premise of superdeterminism is that things which we deem to be uncorrelated are in fact correlated in such a way as to respect Bell inequalities while still preserving local realism.
The bell inequalities have been shown to hold true when the measuring 'decision' was left to signals coming from a pulsar some untold number of millions of light years away, implying that the particle you just generated today has its hidden state correlated with the state of that pulsar that many million years ago. So it seems that nature must be much more highly correlated that we would expect, so I don't know what you would trust as pseudo-random anymore.
Perhaps at some point we will be able to do the same triggered by fluctuations in the cosmic background radiation, proving that either quantum entanglement is not both local and real, or that the state of the two particles you just generated was decided at the big bang in such a way as to seem like the Bell inequalities are true.
