Most people who drive any sort of car don't know what a carburetor is. Heifermann's comment is hyperbolic, but not that far off the mark. There has to be a huge percentage of facebook and myspace users who NEVER use email. My own inbox is primarily turning into a collection box for online receipts and bank statement notices, just as my real-life mailbox has turned into a collection box for ... bank statements and other administrative paperwork I never read.
But you really think that people in college -- people who receive transcripts, syllabuses, and class announcements through email -- are the group most likely to abandon their inboxes?