The only entity that can end prohibition altogether is Congress. When they setup the drug laws, they made them so that there would be a massive chain of signoffs, and so that any single unreasonable person could stop the whole thing.
This flowchart makes it seem way more difficult than it actually is. The USAG and the Secretary of HHS both serve at the pleasure of the President. Biden cannot unilaterally reschedule marijuana but he can tell the USAG and Secretary of HHS to do what it takes to reschedule it.
Biden pretending he can't make this happen is equivalent to Tim Cook pretending he can't get Jeff Williams to do something. Everyone ultimately responsible for changing the schedule ultimately reports to Biden.
https://www.brookings.edu/blog/fixgov/2015/02/13/how-to-resc...
The only entity that can end prohibition altogether is Congress. When they setup the drug laws, they made them so that there would be a massive chain of signoffs, and so that any single unreasonable person could stop the whole thing.