I have worked on deployable structures of scale using some of the principles of origami. The main obstacle to making successful structures that fold or deploy is that precision is very important, because once you have large joints in different planes things like deflection and fabrication tolerances become critical especially if you want to do more than a single unfold or deployment. A great book by Lang is "Twists Tilings and Tesselations" (2018) that goes over the mathematics of origami and folds. The Hoberman sphere works fine as a small toy, but imagine it built up to a sphere of size not in zero gravity and having to be open and closed several times. Engineering challenges that could lead to some pretty nifty deployable buildings on the Moon, Mars, and elsewhere.