I'm not so sure, at least I know plenty of people in tech hubs that are in a similar position. Certainly anything that reduces the number of jobs you can accept will limit your opportunities, but I'm not sure being open to in-office would immediately solve the problem.
In the end it doesn't matter. Due to family concerns relocation is not an option, and anything local would be a huge pay cut. I'll go that route if I reach the point where I need to, but I'm holding off for now.
You might have to take a paycut even working remotely. A lot of companies now pay what you'd expect locally rather than in a tech hub. So, if you worked remotely from San Francisco you'd earn more than if you worked remotely from somewhere rural.
In the end it doesn't matter. Due to family concerns relocation is not an option, and anything local would be a huge pay cut. I'll go that route if I reach the point where I need to, but I'm holding off for now.