There are a few categories of apps that can get away with non-native look and feel, or even thrive based upon actively doing their own thing in ways that work better for what they are. Blender is a member of such a category. Most things are not.

(Games are the most obvious category. Blender belongs to what I might call 2D/3D design, a category which would include tools like GIMP, Inkscape, FreeCAD, Photoshop, Illustrator, AutoCAD—all ones that can go fairly fully native, but can also benefit from deliberate deviation in both look and feel.)