Lisp is the extension language :) Everything so far is Clojure + ClojureScript with the language backends written in the language they support (python in python and so on)
How about Stallman's idea for GUILE (Scheme) uber-alles. Do source-to-source translation of approximations of the supported languages to Clojure. This would allow everyone access to almost everything in the tool.
I think the popularity of CoffeeScript is a datapoint against your idea. I bet a lot of pythonistas use it because it's less of a shift than Javascript. Also, in such a system, if people are curious enough, they will learn the native implementation language as a result of the system being so constructed.