I was lucky enough to listen to Souders talk at Fluent this past week. He talked about Front-end SPOFs and specifically an experience in Beijing where Business Insider didn't load because of a third party widget (Twitter, in his case) being blocked.
One site he mentioned (and great for testing) was webpagetest.org.
Before you deploy, test with facebook.com and twitter.com sent to 0.0.0.0 in your hosts file. Facebook has been getting more reliable, so it's possible to develop a feature and deploy it without Facebook breaking.
For this purpose, 1.1.1.1 is probably an OK IP to use for testing. It's in a range that's technically a routable public IP, but which will almost certainly never be announced (as it receives a ridiculous amount of bogus traffic).
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The 1x1 pixel trick he mentions is a wonderful little hack. Such an elegant solution to keeping your clients' sites working without even requiring site managers' action.
One site he mentioned (and great for testing) was webpagetest.org.
Here are the slides from the talk: http://stevesouders.com/talks.php
He blogged about the issue here: http://www.stevesouders.com/blog/2012/03/28/frontend-spof-in...