I'm curious about this too. Use something like Tineye and check new Funnyjunk submissions against The Oatmeals image archive. Aside from the hardware it's a tiny amount of work for 1 human to monitor the results.
...until the company starts to monitor sites like Reddit and Imgur and suddenly, all the re-hosted stuff that lands on Reddit on a daily basis leads to the "good" Imgur being sued by the machine that formerly was used to combat the "evil" Funnyjunk.
Sued? No they'd be served with DCMA takedown notices. Which is perfectly fine in my book.
If the content creators don't want their content on Imgur then they should be able to take it down.
Nothing is preventing people from linking directly to the content creators site, redditors are just apathetic and would rather just click through imgur links.