We have a house more expensive than that, an interest rate around the top of that range, live in a state with somewhat high property taxes, and had at least $4k in health care spending on top of insurance premiums (no big problems, that's just what a handful of minor kid-related issues in a year costs in the US) and still wouldn't have done better itemizing. We took the standard for 2024.

We're ~92nd percentile for household income.