I used to have terrible back, shoulder, and wrist problems.

Then I bought a Herman Miller Mirra, got decent wrist-rests^ for mouse and keyboard, and took up bike riding and other forms of exercise.

I can't say for sure which of those three had the biggest effect, as I made all those changes at once, but I definitely don't hurt anymore.

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^ Definitely recommend the IMAK ergoBeads products for this!