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Most people think of protein as a good thing, but <that's> what stimulates the hormone IGF-1 to be secreted, which is necessary for growth of all kinds

When you say "that's" are you referring protein and specifically its presence or absence? It would be interesting indeed to see more research on this as well if possible dimensionalize by not only retsricted/normal kCal but at variations in % kCal by proteing etc. It would also perhaps be very interesting to understand if the variations align as mean values above and below "normal" caloric restricion. Ie, imagine a polar explorer who is operating in caloric deficit yet at high exertion thresholds for days on end. And/or contrast this with caloric restriction in the sense of < normal 2200 per day (or whatevs).



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