Seth shows a lot of courage to do this. I have done three start ups. My first one was successful and got bought by Lexis/Nexis... but it wasn't very lucrative. The second one was a complete disaster and I spend $40 million on a pipe dream and my VC's had to take me out. The third one was a success still waiting to materialize as it was sold and I have yet to see the dividend. But at ever step i made lots of mistakes (including falling behind on payroll taxes) and each of these were learning opportunities. I give kudos to Seth for sharing this and am more hopeful now than before that he can make Amicus successful in the long term.