As terrible as it is to write this, (while still really early and I'm far from a NTSB expert), but if you had to pin a failure event on human or design, you'd be better to have it rest on human cause.
Resolution could then be practiced or automated out of existence, versus structural design that could take years to resolve.
I don't see any way this could be anything other than a design problem. The engine can't be throttled, so there are no circumstances under which you'd want to feather during the burn. So there should have been, at the very least, an interlock to make it impossible. Either there was no such interlock, or it failed. One way or the other, I can't see how the root cause could end up being pilot error.
A better example might be the the Mercury Project, which made 17 unmanned test flights before attempting to put a man into suborbital tests, and a few more before into orbit.
There's also the relaxed stability concept (https://en.wikipedia.org/wiki/Relaxed_stability), which I assume is what you were referring to with the reference to the B-2, and per that Wikipedia article the MD-11 airliner employs it (although back when it was flying passengers if I'd had any option at all I'd have avoided flying in one, for many reasons I and others don't consider it to be a safe plane. And its parent DC-10 was the least safe wide body airliner in its days; as some people said before, and probably still now that Airbus is on the scene, "If it ain't Boeing, I ain't going").
As I noted in another posting, the new fuel used in this flight meant new patterns of vibration, some of which can only be found/tested in free flight. Sometimes you can get away with that, e.g. the Space Shuttle was never unmanned, then again the first flights had only two crew and they had SR-71 survival systems (ejection seats and intense environmental suits).
Isn't one of the advantages of the hybrid solid fuel / liquid oxidizer design that it can be throttled to some extent by cutting off the oxidizer using a valve?
I do agree that I can't see why a feather during a burn would ever be desired, but we'll have to wait for the NTSB to see whether the flaw was in the design or manufacture.
Resolution could then be practiced or automated out of existence, versus structural design that could take years to resolve.
RIP Michael Alsbury.