It's very similar to Eclipse in terms of general layout/workflow. Shortcuts might differ a bit, but nothing major. Many of the tasks which were somewhat awkward in Eclipse like managing libraries are simpler in IntelliJ/Android Studio. Android Studio's integration with the Android SDK is significantly better than Eclipse+ADT, and the build system seems to work much more reliably for me, when it would randomly fail for me frequently in Eclipse.

I've been using Eclipse for my day job for the past 4 years and I have no issue switching between that and Android Studio.