I think the path to "Hello world!" ends up being a bit longer and the buy-in cost a little higher since Clojure isn't really a fitting language for scripts. As soon as you've got an application that requires more than a single namespace, though, the languages' strengths start to come into play.
If Clojure was better suited for scripting, that would amazing. It's one area the language could be a bit better about handling. Setting a quick leiningen project to create a "Hello world!" certainly works and is relatively quick, but that includes a lot of leiningen baggage too.
